The cees dekker Diaries
The cees dekker Diaries
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‘Yes, that is definitely about right. I seek out a physical comprehension of biological techniques inside of a bottom-up way. I believe you could possibly distinguish three lines of exploration in my team in the meanwhile. The main issues chromosome framework: How does one get a metre-extended DNA polymer folded and organised in this type of microscopic cell? We've got formulated visualisation procedures that enable us to review how, such as, SMC proteins loop DNA (video on Youtube) as a way to Make up chromosomes.
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Like a individual, I contain the biblical assignment to explore and use almost everything in generation for the good thing about my neighbour. I don't knowledge any conflict between faith and science. On the contrary, my faith stimulates me to try and do science, to generally be open-minded on the earth.’
Nanofabrication of electrodes with sub-five nm spacing for transportation experiments on single molecules and metallic clusters
2015, discovery that condensin can be a very adaptable protein framework; and initial detection of DNA knots using nanopores
The coiled-coil in the human Rad50 DNA repair protein has certain segments of increased overall flexibility
Since 2000 he moved to one-molecule biophysics and nanobiology, with exploration from DNA supercoiling reports of nucleosomes and DNA mend proteins to DNA translocation by means of nanopores. Lately his investigate has centered on learning mobile division with microorganisms on chip, whilst his ultimate desire is inside the direction of knowing synthetic cells.
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‘You should not just take into consideration the inquiries of tomorrow, and also look at the issues of your working ceesdekker day immediately after tomorrow’
1). The existing–voltage curves showed major modulations with gate voltage, even at space temperature, which was according to band bending within a ~0.six eV bandgap semiconducting nanotube. These info also confirmed that the conductance may very well be modulated by six orders of magnitude by transforming the gate voltage. The results of the perform — a home-temperature transistor created from one carbon nanotube molecule — had been released in Nature in May possibly 1998.
Screening pseudotopological and nontopological styles for SMC-driven DNA loop extrusion in opposition to roadblock-traversal experiments
1999, first measurement on the wavefunction of single molecular orbitals of carbon nanotubes; and discovery of kink heterojunctions of carbon nanotubes which gave decisive evidence for just a new Luttinger description of interacting electrons in nanotubes
Electrical transport in monolayers of phthalocyanine molecular wires and AFM imaging of only one wire bridging two electrodes
Stable-point out nanopores have tested to generally be a surprisingly flexible probe for solitary-molecule analysis of DNA. I will explain many of our the latest conclusions – precisely DNA knots – and our endeavours to extend the capabilities of sound-state nanopores even even further, from the course of solitary-protein detection, graphene nanopores, plasmonic nanopores, and DNA origami nanopores.